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In the Spotlight

January 03, 2000

Think Zinc: Do Zinc Lozenges Really Work In Fighting Colds?

By Michael Woo-Ming M.D., MPH
Personal MD.com Medical Contributor

 

I don't have to tell you we are in the middle of cold season. (Do you want to see my waiting room?). One question that pops up on occasion are the use of zinc lozenges.

Long advocated by alternative practitioners and at health food stores, zinc lozenges have long been touted as a supplement effective against colds. Can they really combat the common cold? Here's what we do know:

What is zinc?

Zinc is a trace mineral that is essential for our body. It is found in muscle, our bones, skin, liver, pancreas, and other organs. Next to iron, it the most available trace mineral in the human body.

Zinc
Zinc is a trace mineral that helps boost immunity, repair wounds, maintain fertility, synthesize protein, helps cells reproduce, and preserves vision. More than 300 enzymes in the body need zinc in order to function properly. A deficiency of zinc may impair the body's immunity and immune function.
Good food sources of zinc include oysters (the best food source), meat, eggs, seafood, tofu, black-eyed peas, seeds and nuts, whole wheat, rye, oat, and wheat germ. However, the average diet often does not provide the recommended daily allowance for zinc. The U. S. Recommended Dietary Allowances are:

Infants under age 1 year: 5 mg
Children age 1 to 10 years; 10 mg
Males age 11 and older: 15 mg
Females age 11 and older: 12 mg
Pregnant women: 15 mg
Nursing women: 16-19 mg

Zinc is available individually as a nutritional supplement (zinc sulfate, zinc gluconate, zinc citrate, zinc picolinate, and chelated zinc), or contained within a multivitamin and mineral supplement. If you take a zinc supplement, avoid taking it at the same time as high-fiber foods as they may interfere with the absorption of zinc. Zinc interferes with the absorption of copper, iron, calcium, and magnesium, so if you are taking zinc for a long time, a multimineral supplement is usually recommended.
Zinc may also cause some drug interactions, so be sure to talk to your doctor before taking a zinc supplement, especially if you are also taking other medications.

How does zinc work in stopping colds?

No one knows for sure but there are a number of theories. The zinc molecule itself is the same size and shape of binding sites on our cells where rhinoviruses (the virus responsible for colds) can attach and cause infections. Other studies suggest zinc prevents replication of cold viruses, preventing them from growing.

Has any research been done on zinc?

Some work has been done, but nothing cementing a universal recommendation by doctors. Since zinc fell under the category of "alternative medicine", there were very few initial studies done by the medical establishment. However in the 1980s various formulations of zinc have been tried with some success.

One study by the Cleveland Clinic showed a 48 percent reduction in duration of symptoms if taking four to six zinc lozenges a day. Compared with those taking a placebo (sugar pill), those who took zinc lozenge had a significantly less amount of days in coughing, headache, nasal drainage, and sore throat. In a literature review conducted by Canadian physicians, it was concluded that zinc lozenges were fairly effective in treating the common cold.

I want to try zinc. How should I take it?

It appears zinc lozenges are most effective if taken immediately after the outbreak of symptoms, ideally within 24 hours. Then it is recommended that a lozenge be taken every two hours while awake for maximal efficacy. As with all medicines, you should let your doctor know that you are taking zinc supplements.

Any side effects?

If you haven't tried zinc lozenges, it is certainly an unpleasant tasting experience. One of the caveats these studies demonstrated was that a number of people dropped out of the study, because of zinc's terrible taste. It may also produce nausea and mouth irritation, also limiting patients taking it on a regular basis.

In reviewing the literature myself, it appeared to me that there was enough information suggesting zinc has at least some therapeutic effectiveness against colds. I think the bad taste of zinc lozenges definitely would prevent me from taking them six times a day.

Recently, a zinc nasal spray has come out which might increase compliance. However, no studies as of yet have demonstrated if it is as effective as taking zinc orally. So I guess to sum it all up: If you believe the mantra that good medicine must taste bad, zinc certainly fits the bill!

References:
Zinc gluconate and the common cold. Review of randomized controlled trials. Marshall S - Can Fam Physician - 1998 May; 44: 1037-
42 Zinc lozenges for the common cold. Macknin ML - Cleve Clin J Med - 1999 Jan; 66(1): 27-32.

 

 

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