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Genes Can Increase Heart Risk Even In Those Who Are Fit

ATLANTA -- Gary Peter's family history came calling one hot, summer morning two years ago.

Knock. Knock.

The 36-year-old felt a shoulder pain as he got ready to go to work. The day before, he had felt nauseous after a run. It was during his morning shower that Peter's ticking genetic time bomb really exploded. A heart attack got him, just as it had his mom and dad. Hours later, a gurney whisked him toward emergency angioplasty surgery.

``Both my parents have heart disease, so I knew I was predisposed to it,'' said Peter, a Georgia Tech professor. ``But I didn't think it would strike at such a young age.''

At 5-foot-10, 170 pounds, fit, active, a nonsmoker who ate a low-fat diet, Peter was not your typical ``heart attack waiting to happen.'' Even the paramedics and emergency room doctors thought so.

``They were resistant to believing I was actually having a heart attack. They didn't even turn on the siren and they drove side streets to the hospital. My wife beat them there,'' he said. ``There were no apparent risk factors other than my genetics.''

Some 58 million Americans have cardiovascular disease, and of those, half have a family history of bad hearts hanging over them, called a genetic predisposition. The magnitude of risk increases for a person based on how many first-degree relatives -- mother, father, brothers, sisters -- died before age 55 or were hospitalized for heart disease before age 55. If two or more relatives did, risk increases 53 percent; one relative, 35 percent. If a first-degree relative suffered cardiovascular disease at any age, there's an added risk of 6 percent to 16 percent of suffering cardiovascular problems, a 1986 University of Utah School of Medicine study found.

``Genetics is one of the most important predictors of heart disease,'' says Dr. Laurence S. Sperling, cardiologist at the Emory HealthCare Heart Center and medical director of the Emory HeartWise Risk Reduction Program. ``The first-degree relatives of mom, dad and siblings are most important to consider: Were they smokers or obese? Some people can do everything right -- eat right, exercise and not smoke, yet they still develop heart disease at a young age.''

Case in point -- Peter, one of Sperling's patients. Peter says his father was a longtime smoker and his mother had high blood pressure. Both had elevated cholesterol, something Peter assumed he was controlling with a good diet and exercise. However, the cause of his heart attack was a complete blockage of a major heart artery. A blood clot had broken off from the fatty cholesterol plaque forming within the artery.

Peter's overall cholesterol was 250 -- a reading of 240 or over immediately raises a red flag for doctors, who usually order more tests. But Peter says he didn't know his cholesterol was so high.

Often, the first sign of high cholesterol is a serious cardiac event, the reason why heart disease and high blood pressure are often called ``the silent killer.'' According to the American Heart Association, 57 percent of men and 64 percent of women who die suddenly from heart disease had no previous symptoms. Overall, about one-third of people suffering heart attacks die.

Despite the luck of personal family history, individuals can still do plenty to keep themselves from becoming a heart attack or stroke statistic. Maybe your dad smoked -- increasing his heart disease odds by 300 percent, or maybe your brother was obese, ate high-fat food, and acquired Type 2 diabetes, a highly lethal combination.

``About 50 percent of risk of heart disease comes from genes and 50 percent-plus comes from environmental factors,'' Sperling says.

These are the things you do or don't do every day, such as smoking, taking a brisk walk or other regular physical activity, keeping your weight under control, or gobbling potato chips at lunch, hamburgers for dinner and never, ever turning down birthday cake at the office.

Yes, yes, yes, we know we are tempting fate by playing Russian roulette with these diabetes and heart-disease risk factors. This is where hospital and health care preventative heart disease programs come in, such as the ones at Emory, Piedmont, St. Joseph's and Northside hospitals -- Atlanta's major cardiac wellness centers.

Emory's HeartWise program, going into its third year, not only works with people who've suffered heart problems, but those who don't yet feel any symptoms. Helping people with heart disease family risk learn how to lower risk factors they can control is a growing trend in cardiovascular care.

``You can't change your genetics,'' Sperling says. ``But you can greatly alter your genes reaching their potential. Heart disease is the No. 1 cause of premature death in this country, but people still seem to be under the impression it's a disease of old men.''

The statistics belie that. Though only 1 in 10 women will develop breast cancer if they live to age 75 (1 in 8 if she lives past age 85), 1 in 2 women will have heart disease. And 35 percent of all cardiovascular disease deaths are premature -- before age 75.

At age 39, Sheryl Winn knew she was at risk because of her weight, high cholesterol and family history. But even Winn, a former cardiac nurse, didn't know just how susceptible she was to ending up like her mom and dad. Her mother died following a balloon angioplasty to open clogged heart arteries, and her father, now 74, underwent two bypass surgeries following a heart attack.

A blood test revealed Winn had high levels of homocysteine, an amino acid that damages arterial walls if it concentrates in the blood. Winn's condition is caused by one of 38 genes identified as heart disease markers. Folic acid supplements help control it. Winn also is using her treadmill at home and has altered her meals after a dietitian scrutinized what she ate. She's lost 43 pounds and is trying to lose 50 more and lower her cholesterol before resorting to prescription drugs.

``Prevention is the real key with cardiac disease,'' says Winn, who teaches nursing at Emory University and lives in Dallas. ``Any time you have a heart attack, you lose some function of the heart muscle and you never get it back.''

Winn is signing up for all the HeartWise tests and consultants, even though her health insurance is not picking up the entire tab, a common occurrence when it comes to heart prevention costs. Checking insurance coverage is part of the HeartWise services. Sliding scale fees can be charged based on income, and a scholarship fund established by patients with insurance helps those lacking coverage. Medicare does cover most costs.

Insurance paid for Winn's initial visits and blood work, but not her nutrition counseling, and it probably won't pitch in for her to join the clinic's exercise facility, she says. Winn also expects to be left with the $500 bill to undergo an Ultrafast CT scan that could spot plaque forming.

``I'm not having any symptoms now of heart disease, but I want to know if there was some potential blockage because then I can do something about it,'' Winn says.

Assessing risk for heart disease is done with a complete family history and physical examination. Patients can also be put on a treadmill tethered to a heart monitor to test cardiac function, or undergo an echocardiogram, where they hear the drum of their heart and see the heart muscle. An action plan follows, tailored to each individual through appointments with exercise physiologists, dietitians and doctors who may prescribe drugs to treat cholesterol, blood pressure or diabetes. Many classes are also offered for reducing stress, quitting smoking and managing blood pressure.

Three floors above the Emory heart clinic is a new workout facility chock-full of every conceivable exercise machine to raise a person's heart rate, along with weight machines. Yoga, cardio-kickboxing and aerobic classes are also offered. A nurse keeps close tabs on patients, but the facility also is used by healthy Emory employees who pay a user fee.

At Piedmont Hospital's Fuqua Heart Center of Atlanta, two programs are geared toward those who've already experienced a cardiac event: Inpatient education and 12 weeks of early outpatient classes that include exercise, EKG treadmill monitoring, nutritional assessment and stress and smoking cessation classes.

A third program is geared toward prevention for those with heart-disease risk factors or for individuals with at least three months' time since their cardiac event.

``We think it's good for people with risk factors to be in with people who've undergone heart attacks or cardiac surgery,'' said Dr. John Cantwell, Piedmont's co-director of preventive cardiology and cardiac rehab. ``They learn from one another.''

St. Joseph's Hospital offers a ``Heart School,'' open to the public to learn how to ward off heart disease. It also sees hundreds of people at its wellness center who haven't experienced any cardiac symptoms and want to keep it that way, as well as those who've undergone bypasses and heart transplants.

``We see a lot of obese people and people with hypertension,'' says Mark Ervin, St. Joseph's wellness/rehab manager, ``but the staff is qualified to take care of them.''

Despite the heart heritage that caught up to Peter, he says he believes he can beat, or at least stall, the disease from rapping again on his door.

``Being a scientist, I may look at it differently. I know there's a genetic component, but it's not cancer, it's heart disease,'' says Peter, whose cholesterol has dropped to 170 through exercise, dietary changes and medication that's monitored through the Emory HeartWise program. ``At least with heart disease, you have more self-control over it. You can play a more active role. It's a day-to-day disease. I have to be vigilant.''


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