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Rodale's Healthy Living: Do You Really Know Your ABCs?

Here are some little-known and highly motivating reasons to reacquaint yourself with your supplements.

VITAMIN C

The most popular vitamin supplement in the U.S., vitamin C is a staple in refrigerators and medicine cabinets nationwide for the express purpose of relieving cold symptoms. But there's increasing evidence that vitamin C may not only keep your nose from running; it may keep you running. Literally. One of the first symptoms of vitamin C deficiency is fatigue, notes Balz Frei, PhD, a professor of biochemistry and biophysics, and director of the Linus Pauling Institute at Oregon State University in Corvallis.

Vitamin C is required for the synthesis of carnitine, which transports fatty acids into the mitochondria, the tiny powerhouses that generate energy inside cells,'' he explains. ``If you don't have enough vitamin C, you can't synthesize carnitine, and so you can't convert all the fatty acids into usable energy.''

While its true that carbohydrates are the main source of energy for most of our body parts, fatty acids are the major sources of energy in the heart and skeletal muscles. And these organs are particularly vulnerable to carnitine shortage, Frei says.

How much is enough? Only about one out of every four Americans gets less vitamin C than the Daily Value of 60 milligrams (mg), Frei says. But he points out that the bigger question today isn't how much C is enough, but rather how much is optimal for good health. Frei believes that the magic number is 200 mg a day. Ingest more than that, he says, and your body won't be able to hold onto it.

Vitamin C may help you handle stress with finesse by assisting your adrenal glands in the production of epinephrine and norepinephrine.

``These hormones are responsible for mobilizing energy so that you can respond appropriately to stressful situations,'' Frei explains.

CALCIUM

The bone builder that helps your muscles too -- including your heart. Ninety-nine percent of all the calcium found in our bodies is exactly where you'd expect it to be: in our bones. What you might not expect, however, is that calcium is also vitally important for muscles. In fact, in order to contract and relax properly, muscles depend on calcium.

Adequate calcium in the cells is so important to muscle function that if you're not getting enough through your diet, your body pulls calcium from your bones. Over time this can lead to osteoporosis. And one muscle that especially depends on the right amount of calcium is the heart.

How much is enough? Between the ages of 19 and 50, you need 1,000 mg a day to ensure strong bones and a strong heart. Over 50, 1,500 mg of calcium a day is recommended.

If you want to tame the mood swings and depression of premenstrual syndrome (PMS), try calcium. Women with PMS who took 1,200 mg of calcium carbonate every day for 3 months found that their symptoms were reduced by 45 percent.

VITAMIN D

Calcium's crony may help with psoriasis, diabetes, and even cancer Sure, vitamin D allows bones to harden. But forms of vitamin D are currently being studied for the treatment of breast, prostate and colon cancers, as well as melanoma, a deadly type of skin cancer.

One form of vitamin D, a skin cream, appears to cure up to 70 percent of people with psoriasis. The mechanism behind all these miracles is the fact that vitamin D promotes cell differentiation. Like a traffic cop, it directs developing cells in the right direction, toward their proper, mature form.

What's more, vitamin D almost certainly plays a role in the development of type 1, or insulin-dependent, diabetes -- and it may even help prevent the disease.

``D is needed for cells in the pancreas, called islet cells, to produce insulin, the hormone that allows cells to take up blood sugar,'' explains Hector DeLuca, PhD, chairman of the department of biochemistry at the University of Wisconsin in Madison.

In animals with an inherited tendency to develop type 1 diabetes, supplemental vitamin D helps prevent the disease. And while studies haven't yet been done on humans, researchers surmise that D may have a similar effect on us.

Vitamin D deficiency is a real problem in the U.S., and it becomes increasingly likely in people 50 and older, says Michael Holick, MD, PhD, chief of the section on endocrinology, nutrition, and diabetes at Boston University Medical Center. You can take a multivitamin/mineral supplement that offers the Daily Value for vitamin D of 10 micrograms (mcg) or 400 international units (IU). But some studies show that older people can benefit from up to 800 IU a day.

Did you know that milk may let you down?

``Milk may not be as reliable a source of vitamin D as many people think it is,'' Holick says. His students analyzed samples of milk from all the regions of the US and western Canada and found that many of them didn't contain as much D as they claim. In fact, one out of every six samples of fat-free milk contained no vitamin D at all.

VITAMIN B6: A DIABETICS BEST FRIEND

If you suffer from premenstrual syndrome (PMS), you may be familiar with vitamin B6. It regulates a number of hormones, including estrogen and progesterone, and for some women is an effective defense against PMS. But odds are that your are unfamiliar with B6s more serious role: a possible defender against many serious complications from diabetes, including kidney damage, nerve damage and cataracts.

Yale University researchers recently found that diabetics who took 50 mg of vitamin B6 three times a day for 6 weeks experienced a big drop-off in the glycosylation of hemoglobin, a protein that is found in red blood cells.

Blood levels of B6 are low in about 25 percent of people with diabetes.

How much is enough? You can safely take up to 100 mg a day without risk.

FOLIC ACID

The little-known cancer fighter. Most women of childbearing age know that they need ample folic acid to prevent serious birth defects in their unborn baby. What you may not know is that adults need folic acid, too, to prevent serious diseases such as cancer.

Folic acid is essential for DNA and RNA synthesis, meaning that it has to be on hand for your body to make the genetic material that enables cells to divide to make more cells. As a result, when folic acid is in short supply, DNA synthesis slows, and cells lose their ability to divide and multiply.

In pregnancy, this can set the stage for serious birth defects. In the blood, it can cause anemia (a lack of red blood cells). And in some cases, it can encourage your body to produce abnormal cells, a condition called dysplasia that can lead to cancer.

``Folic acid helps make the building blocks, called bases, which are strung together like pearls on a string to form DNA,'' explains Barry Shane, PhD, chairman of the department of nutritional sciences at the University of California at Berkeley.

Cancer develops because the chain of bases that ``string of pearls'' in a cellis damaged, resulting in mutations in the DNA. And folic acid deficiency has recently been strongly linked to DNA damage and dysplasia, or precancerous changes, in the cervix, colon, and lungs.

How much is enough? Most people get about 200 mcg of folic acid a day, or half the Daily Value. But with folic acid-fortified breads and cereals now on the market, daily intake could increase to 300 mcg a day. But that still leaves a 100-mcg daily deficit. Bottom line: You have to supplement. Most multivitamins contain 400 mcg of folic acid.

Did You Know? Folic acid may spiff up your smile. In fact, several studies have shown that it can reduce inflammation, bleeding, and plaque buildup on teeth when taken as a supplement or used as a mouthwash.

``Your mouth contains the fastest-dividing cells in the body,'' explains Liz Collins, ND, a naturopathic physician and co-owner of The Natural Childbirth and Family Clinic in Portland, OR. ``And any cell that divides quickly needs folic acid to replicate properly.''

Dr. Collins recommends popping between 400 and 800 mcg of folic acid a day to treat gingivitis. Or gargle with a folic acid mouthwash twice a day to get up to the 800 mcg that she recommends. Simply empty a folic acid capsule into about 4 ounces of lukewarm water, stir, swish it in your mouth for a couple of minutes, then swallow.

Repeat that until you've finished the solution.

OPTIONAL SIDEBAR

VITAMIN C AT A GLANCE

Alias:

Ascorbic acid. What does it do? Protects all cells in the body from free radical damage and toxins and allows the body to convert fatty acids into fuel and to produce the ``stress'' hormones epinephrine and norepinephrine.

Why take it?

To help prevent or treat any condition or disease associated with free radical damage, including bacterial and viral infections, cancer, asthma, diabetes-related organ damage, chronic inflammatory diseases such as rheumatoid arthritis, recovery from surgery or injury, and exposure to toxins.

Who needs it most?

Smokers and people routinely exposed to cigarette smoke; people with viral or bacterial infections; people with diabetes, high cholesterol, cardiovascular disease, cancer, or chronic inflammation; and people who take aspirin or barbiturates daily.

Best eats for C:

Red chili peppers, red and green bell peppers, kale, parsley, broccoli, brussels sprouts, cabbage, strawberries, cantaloupe, and citrus fruits.

Tip:

Divide your dose in two. Take 100 milligrams (mg) with breakfast and 100 mg with dinner to keep up blood levels of vitamin C throughout the day.

OPTIONAL SIDEBAR

CALCIUM AT A GLANCE

Forms:

Carbonate, citrate, citrate-malate, lactate, dicalcium phosphate, gluconate.

What does it do?

Builds bone and teeth and also contributes to regulation of muscle contraction, clotting of blood, transmission of nerve impulses, secretion of hormones, and activation of some enzymes

Why take it?

To prevent osteoporosis and high blood pressure.

Who needs it most?

People who don't eat many dairy products (vitamin D aids calcium absorption) and breast-feeding women.

Best eats for calcium:

Milk and milk products, sardines with bones, kale and calcium-fortified orange juice.

Caution:

Large doses of calcium interfere with the body's ability to absorb other minerals, such as iron, zinc, copper and manganese. To maximize absorption of supplements that contain these minerals, take your calcium supplement separately from them.

OPTIONAL SIDEBAR

VITAMIN D AT A GLANCE

What does it do?

Promotes the absorption of calcium and phosphorus from foods to increase bone strength, helps skin cells grow normally, and aids the pancreas in producing insulin. Why take it? To prevent osteoporosis, psoriasis, and possibly type 1 diabetes.

Who needs it most?

People who don't eat many dairy products and those who don't get much exposure to sunlight.

Best eats for D:

Fortified milk, fatty fish such as mackerel and salmon, egg yolks and liver.

Caution:

Large doses (more than 2,000 international units [IU] a day) over several months can cause kidney stones, calcium deposits in your kidneys and heart, which can be fatal. If you're taking several nutritional supplements, including ``animal extracts'' such as liver extracts that contain undisclosed amounts of vitamin D, consult your doctor to be on the safe side.

OPTIONAL SIDEBAR

VITAMIN B6 AT A GLANCE

Alias:

Pyridoxine. What does it do? Helps relieve premenstrual syndrome (PMS), morning sickness, and carpal tunnel syndrome; possibly reduces the risk of heart disease, kidney stones and complications from diabetes.

Who needs it most?

Elderly people who are poor eaters, alcoholics, people taking drugs that interfere with B6 absorption, and those with intestinal absorption problems.

Best eats for B6:

Chicken, fish, meat, spinach, broccoli, and bananas.

Caution:

Doses of 100 milligrams (mg) a day or more for several months can result in sensory neuropathy, or numbness in the hands and feet, which usually goes away once the dosage is reduced.

OPTIONAL SIDEBAR

FOLIC ACID AT A GLANCE

Aliases:

Folate and folacin. What does it do? Ensures production of a cells genetic material DNA and RNA.

Why take it?

It prevents birth defects and helps to reverse possible precancerous cell changes in the cervix, lungs, and colon. It may also reduce blood levels of homocysteine, a risk factor for heart disease.

Who needs it most?

People who use cholestryramine (Questran), a cholesterol-lowering drug; people with cancer; the elderly; women of childbearing age; alcoholics; and smokers.

Best eats for folic acid:

Leafy green vegetables, legumes and seeds.


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