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Discriminating Diseases: Heart, Bone, Digestive Diseases Attack Women Much Differently Than Men, Researchers Reveal

WASHINGTON, Oct 25, 1999 /PRNewswire via COMTEX/ -- Research unveiled at a national conference of the Society for Women's Health Research indicates that gender plays a major role in the underlying causes and effects of heart disease, musculoskeletal health and metabolic/digestive diseases.

A blue-ribbon panel of experts identified the three discriminating areas of disease to women as the next frontier in sex-based biology. The researchers cited findings from more than a dozen studies on women and heart attacks, irritable bowel syndrome, and the occurrence of certain sports injuries to women, as evidence of an abundance of sex-based differences yet to be fully understood. (See list below)

Researchers gathered at the "Annual Update on Women's Health Research: Discoveries and Implications," the Society's Ninth Annual Scientific Advisory Meeting.

"Although women have become more health conscious, we still have such a long way to go in understanding why the most common and deadly diseases discriminate as they do," said Phyllis Greenberger, executive director of the Society for Women's Health Research. "The Society's mission is to call for more sex-based medical research, which will help men as well as women," said Greenberger.

"Researchers used to think of women as 'little men,' but in the past 10 years, science has uncovered biological and physiological gender differences in virtually every organ of the human body," added Greenberger.

Sex-based biology is the field of scientific inquiry committed to identifying the biological and physiological differences between men and women including gender differences found at the system, organ, tissue, cellular and sub-cellular level, and gender differences in response to pharmaceuticals.

The Society for Women's Health Research is the only national advocacy group dedicated to improving the health of women through research. The Society was founded to bring attention to gender inequities in medical research, and continues to make research into gender differences a top strategic priority.

--Heart Disease

* Delayed Onset of Heart Disease: One in nine women in the U.S. aged 45- 64 has clinical evidence of coronary heart disease, whereas after age 65, one in three women has evidence of disease. Disease appears about 10 years later for women than for men, with heart attacks occurring as much as 20 years later.

* Chest Pain and Women: While angina pectoris is one of the first signs of heart disease that is common to men and women, chest pain is not. One study found that 86% of women diagnosed with chest pain never suffered a heart attack.

* Women and Heart Attacks: The mortality difference between men and women is real. Women are less likely to have heart attacks, but when they do, they appear to be at higher risk of dying, especially younger women.

--Musculoskeletal Health

* Women and Sports Injuries: College-age women involved in basketball or soccer tear their anterior cruciate ligaments (ACLs) at a significantly higher rate than college-age men involved in the same sports.

* Osteoarthritis: Is three to four times more common in women than in men. That ratio increases with age.

* Osteoporosis: More than 80% of those affected by osteoporosis are women.

--Metabolism/Digestive Disease

* More Irritable Bowel Syndrome (IBS) in Women: A higher percentage of patients with IBS are women. Evidence is emerging that male and female differences exist in symptoms. Women report longer pain episodes, more bloating, nausea and vomiting, whereas men tend to report having diarrhea.

* Autoimmune Liver Diseases: Women are five times more likely than men to suffer from autoimmune hepatitis.

* Rejection of Liver of Transplant: Rejection of a liver after transplantation is more common when a woman recipient is implanted with a man's liver.


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