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Stomach Cancer Is Often a Silent Killer

OAKLAND, Calif., May 30, 2000 /PRNewswire via COMTEX/ -- NFL player Eric Turner, a member of the Oakland Raiders and a four-year letterman at the University of California, Los Angeles died Sunday in Thousand Oaks, Calif. from the apparent complications of abdominal cancer.

Since his death, the public and sports community has asked numerous questions about this type of cancer and its seemingly aggressive nature.

"Now is the time for education," said Dr. Thomas Fogel, a Ventura, California radiation oncologist and former president of the American Cancer Society's California Division. "People should talk to their doctor and use this opportunity as a bridge to talk about nutrition, diet and other prevention factors," he said.

The following release is a synopsis of current American Cancer Society information about the disease, risk factors and prevention guidelines. Further information can be found by calling 800-ACS-2345 or by going online at www.cancer.org.

Stomach Cancer: What Is It?

Stomach cancer is a cancer that starts in the stomach. The medical name for stomach cancer is gastric cancer. The stomach is only one of many organs in the abdomen in which cancers may develop.

It is important not to confuse stomach cancer with cancers of the colon (large intestine), liver, pancreas, small intestine or gall bladder, because these cancers may have different symptoms, a different prognosis (outlook for survival) and different treatments.

Stomach cancers are believed to develop slowly over many years. Before a true cancer develops, there are usually precancerous changes that occur in the lining of the stomach. These early changes rarely produce symptoms and therefore often go undetected.

It is estimated that 21,500 Americans -- 13,400 men and 8,100 women -- will be diagnosed with stomach cancer during 2000. There will be an estimated 13,000 -- 7,600 men and 5,400 women -- deaths from this type of cancer in 2000. Most people diagnosed with stomach cancer are in their 60s and 70s.

Stomach cancer is much more common in certain Asian, Central European, Central American, and South American countries, especially Japan, Chile, Costa Rica, Hungary, and Poland. It is the leading cause of cancer death in many of these countries and is a major cause of cancer death worldwide.

In the United States, stomach cancer is now only one-fourth as common as it was in 1930. The reasons for this dramatic decline are not completely known but may be related to increased use of refrigeration for food storage and decreased use of salted and smoked foods.

What Are The Risk Factors For Stomach Cancer?

Scientists have found several risk factors that make a person more likely to develop stomach cancer:

-- Helicobacter pylori infection: Long-term infection of the stomach with this bacterium may lead to chronic atrophic gastritis (inflammation and damage to the inner layer of the stomach), a possible precancerous change of the lining of the stomach. Helicobacter infection is also associated with some types of lymphoma of the stomach. But the vast majority of people who carry this bacterium in their stomachs never develop cancer.

-- Dietary causes: An increased risk of stomach cancer is associated with diets containing large amounts of smoked foods, salted fish and meat, certain foods high in starch that are also low in fiber and pickled vegetables. On the other hand, eating whole grain products, fresh fruits and vegetables that contain vitamins A and C appears to lower the risk of stomach cancer.

-- Nitrates and nitrites are substances commonly found in cured meats, some drinking water, and certain vegetables. They can be converted by certain bacteria, such as Helicobacter pylori, into compounds that have been found to cause stomach cancer in animals.

-- Tobacco and alcohol abuse: These habits can increase stomach cancer risk, particularly for cancers of the proximal stomach (the upper portion of the stomach closest to the esophagus).

--Previous stomach surgery: Stomach cancers are more likely to develop in people who have had part of their stomach removed to treat noncancerous diseases such as ulcers. This may be because there are more nitrite-producing bacteria present. Also, acid production goes down after ulcer surgery, and there may be reflux (backup) of bile from the small intestine into the stomach.

-- Being male: Stomach cancer is about twice as common in men than in women.

-- Aging: There is a sharp increase in stomach cancer after the age of 50. Most people diagnosed with stomach cancer are in their 60s and 70s.

-- Blood group A: Blood groups refer to certain antigens (chemicals recognized by the immune system) that are normally present on red blood cells and some other types of cells. These groups are important in matching blood for transfusions. For unknown reasons, people with blood group A have a higher risk of developing stomach cancer.

-- Familial cancer syndromes: Hereditary nonpolyposis colon cancer (Lynch Syndrome or HNPCC) and Familial Adenomatous Polyposis are inherited genetic disorders.

-- Family history of stomach cancer: People with several close blood relatives who have had stomach cancer are more likely to develop this disease.

-- Stomach polyps: Polyps are small bumps or larger mushroom-like growths of the lining of the stomach. Most types of polyps (like hyperplastic polyps or inflammatory polyps) do not increase a person's risk of stomach cancer but adenomatous polyps sometimes develop into gastric (stomach) cancers.

Can Stomach Cancer Be Prevented?

Even though the exact cause of stomach cancer is not completely known, it is still possible to prevent many stomach cancers.

The dramatic decline of stomach cancer over the last 60 years is thought to be a result of people reducing many of the known dietary risk factors. This includes greater use of refrigeration for food storage rather than preservation of foods by salting, pickling, and smoking. To reduce the risk, people should avoid diets that are high in smoked and pickled foods and salted meats and fish.

A diet high in fresh fruits and vegetables can also lower stomach cancer risk. The American Cancer Society recommends choosing most foods from plant sources. This includes fruits, vegetables, breads, cereals, pasta, rice, and beans.

Tobacco and alcohol use can increase the risk of cancers of the proximal stomach (the upper portion of the stomach closest to the esophagus). These cancers tend to be particularly hard to treat successfully. The American Cancer Society recommends limiting the use of alcoholic beverages, if you drink at all. Tobacco use increases the risk for many types of cancer and is responsible for about one-third of all cancer deaths in the United States. If you don't use tobacco, don't start. If you already do, call your health care provider or the American Cancer Society for advice about quitting.

It is not yet known if people without symptoms who have chronic infection of their stomach lining with the bacteria Helicobacter pylori should be treated for this infection. This issue is a topic of current research.

Signs and Symptoms of Stomach Cancer

Unfortunately patients who have stomach cancer rarely have symptoms in the early stages of the disease. This is one of the reasons why stomach cancer is so difficult to detect early.

The signs and symptoms of stomach cancer include:

-- Unintended weight loss and lack of appetite

-- Abdominal pain

-- Vague discomfort in the abdomen, usually above the umbilicus (navel)

-- A sense of fullness in the upper abdomen, just below the chest bone after eating a small meal. Doctors call this early satiety.

-- Heartburn, indigestion, or ulcer-type symptoms

-- Nausea

-- Vomiting, with or without blood

-- Swelling of the abdomen due to accumulation of fluid and cancer cells. Doctors call this malignant ascites.

Some of these symptoms can occur with noncancerous conditions such as a stomach virus or with other types of cancer. However, people who have any of these problems that persist for a long time should check with their doctor, especially if they are over 50 years old or have stomach cancer risk factors.

Since symptoms of stomach cancer often do not appear until the disease is advanced, only about 10% to 20% of stomach cancers in the United States are found in the early stages, before they have spread to other areas of the body.

The American Cancer Society is the nationwide, community-based, volunteer health organization dedicated to eliminating cancer as major health problem by preventing cancer and saving lives through research, education and patient service.

SOURCE American Cancer Society


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