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Most asthma drugs safe during pregnancy

By Nancy Deutsch

NEW YORK, May 29 (Reuters Health) - Pregnant women with asthma should continue to take their regular asthma medication, and should be carefully monitored throughout the pregnancy period by a physician, reports a joint committee comprised of two physician groups.

"In general, (with asthmatics) it's safer to use medications during pregnancy than not to use them," explained Dr. Mitchell Dombrowski, professor of obstetrics and gynecology at Wayne State University in Detroit, and one of the authors of the position paper in Annals of Allergy, Asthma and Immunology. Asthma in pregnancy can lead to complications and even death, so controlling asthma is paramount, he noted.

Initial recommendations on the use of medications for asthma and allergy in pregnancy were issued by the National Asthma Education and Prevention Program in 1993. Since then, more research has been done in this area, and new asthma medications have come on the market, creating a need for these new guidelines, Dombrowski explained.

The position statement is a joint effort of the American College of Allergy, Asthma and Immunology (ACAAI) and the American College of Obstetricians and Gynecologists. The previous recommendations on the treatment of pregnant women with asthma were that these women should continue to be medicated during pregnancy.

"We reiterated that," Dombrowski told Reuters Health. However, "in the past, the recommendation was to use inhaled beclomethasone. Now we're starting to say if a woman is on another inhaled anti-inflammatory steroid, it is probably okay to use that during pregnancy. The newer data is reassuring about drugs other than beclomethasone."

Leukotriene inhibitors are the only drugs for which there is too little data to make any recommendation--except to suggest they not be used during pregnancy unless absolutely necessary until more studies confirm their safety, Dombrowski said.

The authors of the position paper note that in addition to pharmacological management, pregnant women with asthma should avoid asthma triggers such as cigarette smoke and allergens. Furthermore, allergy shots can be continued during pregnancy in patients without severe reactions to the shots, but a pregnant woman who has never had an allergy shot should not start receiving shots at this time.

According to ACAAI, almost 7% of pregnant women have asthma. More information on care of asthma during pregnancy is available at http://allergy.mcg.edu.


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