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In the Spotlight

ERECTILE DYSFUNCTION:
Physical, Treatable, and Without Shame

 
 

By Paul J. Schechter, MD, Ph.D.
Vice President, Drug Development and Regulatory Affairs,
MacroChem Corp. Personal MD.com Advisory Board

A decade ago it would have been impossible to imagine a major public figure admitting to erectile dysfunction. Wide spread misconceptions about the causes of this affliction, unnecessary shame, and a lack of treatment options combined to make it a "secret" shared by up to 52% of all men at some point in their lives.

Former presidential candidate Bob Dole's willingness to discuss and later endorse his use of Viagra, one of the most popular treatments for erectile dysfunction, has now brought this once shadowy affliction out into the open. Bob Dole's brave step could not have come at a better time for the millions of men whose quality of life has been eroded by erectile dysfunction.

Recent research shows that the up to 80% of cases have a physiological basis, and up to 95% of all cases are treatable. Yet despite this good news, as few as one in ten men suffering this condition seek treatment.

Diagnosis

Erectile dysfunction is defined by the National Institutes of Health Consensus Panel as "the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance." That definition is somewhat subjective, which emphasizes that the first diagnosis is a self-diagnosis.

An erection is achieved through a complicated series of muscular and vascular responses to various stimuli. The failure to achieve or maintain an erection can stem from a failure at any point in this series. Once a man brings his concerns to the attention of his doctor, the doctor will attempt to identify this underlying cause.

It is important to note that while the instance of erectile dysfunction increases with age, it is not a consequence of aging, and should not be accepted as inevitable or a "natural" loss of sexual function.

Treatment

Your doctor will want to know of any diseases, injuries, or exposures (such as radiation) that might have a bearing on the dysfunction. The doctor will also review your use of alcohol, tobacco and drugs, both legal and illegal. He or she may about ask your non-sexual activities, such as bicycle riding. (A small number of avid bicycle riders report erectile dysfunction due to the strain placed on the urinary track by hard, narrow bicycle seats.)

It will also be important to learn your erectile history:

when was your last erection achieved?
When did you last have sexual intercourse?
Do you experience spontaneous erections, for example, upon waking?
Does the dysfunction only occur with certain partners or in certain positions?

A physical exam will be conducted to eliminate nerve damage, hormonal disorders or a build up of scar tissue (Peyronie's disease). The doctor may also want to eliminate the possibility of prostrate cancer by conducting a rectal exam. An ultrasound may be performed to observe vascular flow. Estimates suggest that as many as one half of erectile dysfunctions are vascular in origin.

A number of tests may be ordered, including urinalysis, blood counts, or measurements of liver enzymes, creatinine, testosterone, and glucose. The doctor may suggest a nocturnal penile tumescence, which counts the number of erections achieved during sleep. If a specific cause of the erectile dysfunction has been determined, treatment will target the underlying problem and erectile function will be monitored. For dysfunctions caused by nonspecific vascular and neurogenic problems, treatment may include medication, vacuum devices, injections or implants.

The most successful drug therapy has been sildenafil, popularly known as Viagra, which increases cyclic guanosine monophosphate in the penis, which in turn increases blood flow into the penis. There are potential side effects that your doctor will discuss with you. Sildenafil should not be prescribed to men who suffer from angina. Prostaglandin-E1 is an alternative that may be injected directly into the penis or placed into the urethra as a suppository, although it too has potential side effects as well.

Topical formulations of prostaglandin-E1 are being investigated. Vacuum devices simulate an erection by drawing blood into the penis and securing it with a plastic band. There are two types of penile implants. One is an inflatable implant filled with a saline solution through a pump concealed below the scrotum. The other is the insertion of flexible metal rods that are manipulated to angle the penis for sexual activity.

Surveys of implant users find a high degree of satisfaction with the devices. Even though the great majority of erectile dysfunctions have physical causes, many men suffer psychologically as well when experiencing the problem. Perhaps that is why studies show that the success rate is significantly higher when men include their sexual partners in the discussion and determination of the treatment.

References:

Lue, T.F. (1992) Physiology of Erection and Pathophysiology of Impotence in Campbells Urology. Chapter 16, 6th Ed. Editors Welsh et al, Saunders, Phila. pp 709-728.

Melman, A. and Gingell, J.C. (1999) The Epidemiology and Pathophysiology of Erectile Dysfunction. J. Urol 161:5-11.

Laumann, E.O., Paik, A. and Rosen, R.C. (1999) Sexual Dysfunction in the United States JAMA 281:537-544.

Rosen, R.C., et al (1997) The International Index of Erectile Function. Urol 49:822-830.

Feldman, H.A. et al (1994) Impotence and its Medical and Psychosocial Correlates. J. Urol 151:54-61.

Goldstein, I. et al (1998) Oral Sildenafil in the Treatment of Erectile Dysfunction. N. Engl. J. Med. 338:1397-1404.

Althof, S.E. and Seftel A.D. (1995) The Evaluation and Treatment of Erectile Dysfunction. Psychiatric Clin N Am 18:171-192.

Dewire, D.M. (1996) Evaluation and Treatment of Erectile Dysfunction. Am Fam Physician 53:2101-2108.

Greiner, K.A. and Weigel, J.W. (1996) Erectile Dysfunction. Am Fam Physician 54:1675-1682.

Copyright © 1999 PersonalMD.com. All rights reserved.


 
     
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