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Medical Illness May Be Single Greatest Risk Factor For Depression

Mental Health Experts discuss Topic as it Relates To the Graying of America

WASHINGTON, D.C., May 18 /PRNewswire/ -- The rate of depression in people with other medical illnesses, such as arthritis, heart disease, chronic lung disease, and stroke, is alarmingly higher than in that of otherwise healthy adults. Unfortunately, many of those who suffer do so needlessly, according to physician researchers from the American Association for Geriatric Psychiatry (AAGP) presenting data here today at the 152nd annual meeting of the American Psychiatric Association.

In fact, medical illness is the single greatest risk factor in late-life depression. With the rapid growth in the number of older adults -- the fastest growing segment of the U.S. population -- the link between depression and medical morbidity has been gaining attention.

"Many people think that depression is a normal part of aging. It's not. It's not normal to be old and sad," said Barry Lebowitz, PhD, chief, Adult and Geriatric Treatment and Prevention Interventions Research Branch, National Institute of Mental Health. "Depression is an illness and needs to be properly diagnosed and treated. It is a known fact that when you treat the depression, symptoms of other medical illnesses improve."

"Aging brings with it increased risks for chronic medical disease. While chronic illness is stressful, depression is not an inevitable consequence and should be treated. Depression complicating medical disorders in older adults responds well to treatment," added Soo Borson, MD, AAGP president, and associate professor of Psychiatry and Behavioral Sciences and director of Geriatric Psychiatry Services at the University of Washington Medical Center.

"We now have data from research that provide us with an understanding of the issues surrounding depression and co-morbid illness, so as we move into the future, we are better equipped to identify, treat, and someday prevent, this complication."

Lebowitz and Borson were two of four thought leaders who took part in an AAGP-sponsored briefing here today on depression and co-morbid illness, called "Is It All In Your Head? The Relationship Between Depression, Other Medical Illnesses, and the Graying of America."

They discussed the public health implications of depression in the growing population of older Americans, as well as the newly presented research they feel will better our ability to identify, treat, and ultimately prevent, depression in people with other chronic medical illnesses. The AAGP is the leading organization dedicated to promoting the mental health and well being of older people, and improving the care of those with late-life mental disorders.

In addition to the topics presented by Lebowitz and Borson, P. Murali Doraiswamy, MD, Duke University Medical Center, discussed "Heart and Soul: the relationship between stroke, heart disease, and depression," and Gary Small, MD, University of California at Los Angeles, presented "The Brain and Body Connection: the relationship between depression and other medical illnesses."

"We are here today to answer the question on everyone's mind, 'What can we in the United States, with our aging population, expect in the 21st century, and what are our risks for physical and mental diseases?'" said Borson. The answer is that the future looks very good for both baby boomers and their graying family members.

"Older adults are getting healthier, and overall rates of disability are declining," said Borson. "And, in fact, 70 percent of those over 65 years of age have no mental disorder." Borson added, however, that of those who do, the two main sources of mental impairment in the elderly are depression and dementia.

Although the future is bright, Borson pointed out the challenges that still exist. "The challenge for baby boomers who may care for an older adult is to gain an understanding of the issue, identify disorders early, and help him or her get appropriate treatment," said Borson.

"The success rates of drug treatment therapies, for instance, have never been better," said Borson. "Medications are now available to treat depression with little risk of negative interactions with other drugs a person might be taking for another medical illness. In addition, unwanted effects of these drugs are generally uncommon."

The availability of one such medicine, citalopram, has allowed 10 leading academic institutions nationwide to conduct the first-ever clinical trial evaluating depression treatment in people age 75 and older. The results of this study will further elucidate the role of antidepressant therapy in the treatment of late-life depression. Until now, a paucity of data exists regarding antidepressant treatment in the oldest-old.

In addition, older adults typically are a tougher audience for treatment -- they're typically more sensitive to medications and drug interactions, are often on more medications for a variety of ailments, and are more likely to be suffering from chronic illness, than their younger and healthier counterparts. As such, researchers believe that what is learned in this study ultimately may improve depression treatment in all patients whatever their age.

Borson added that prevention is another important key to keeping depression at bay in older adults, or in those people who have other medical illnesses. "Preventive interventions are necessary to control lifestyle risk factors, such as smoking, alcohol, head injury, hormone deficiencies, and poor diet, all of which may make people more susceptible to medical illness, and subsequently, depression," said Borson. "We must identify -- and identify early -- those people who are at risk, and get them help."

This briefing was supported by an unrestricted grant from Forest Laboratories, Inc., and the Parke-Davis division of Warner-Lambert Company. SOURCE American Association of Geriatric Psychiatry




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